Cirazoline (hydrochloride)
Product Specifications
UNSPSC Description
Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full?α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM)[1].
Target Antigen
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cirazoline-hydrochloride.html
Purity
99.65
Solubility
H2O : 33.33 mg/mL (ultrasonic)
Smiles
[H]Cl.C1(COC2=CC=CC=C2C3CC3)=NCCN1
Molecular Weight
252.74
References & Citations
[1]Doze VA, et al. alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behaviorin the mouse.Brain Res. 2009 Aug 18;1285:148-57.|[2]Suzana Assad Kahn , et al. The Anti-Hypertensive Drug Prazosin Inhibits Glioblastoma Growth via the PKCδ-dependent Inhibition of the AKT Pathway. EMBO Mol Med. 2016 May 2;8(5):511-26.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-101300/Cirazoline-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-101300/Cirazoline-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
40600-13-3
Available Sizes
Curated Selection
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