Cirazoline (hydrochloride)

Cirazoline hydrochloride (LD 3098 hydrochloride) is a potent competitive full α1A-adrenergic receptor (α1A-AR) agonist (Ki=120 nM) and only a partial agonist at α1B-AR (Ki= 960 nM) and α1D-AR (Ki=660 nM) [1].

Product Specifications

CAS Number

[40600-13-3]

Product Name Alternative

LD 3098 (hydrochloride)

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cirazoline-hydrochloride.html

Purity

99.65

Solubility

H2O : 33.33 mg/mL (ultrasonic)

Smiles

[H]Cl.C1(COC2=CC=CC=C2C3CC3)=NCCN1

Molecular Formula

C13H17ClN2O

Molecular Weight

252.74

References & Citations

[1]Doze VA, et al. alpha (1A) - and alpha (1B) -adrenergic receptors differentially modulate antidepressant-like behaviorin the mouse.Brain Res. 2009 Aug 18;1285:148-57.|[2]Suzana Assad Kahn , et al. The Anti-Hypertensive Drug Prazosin Inhibits Glioblastoma Growth via the PKCδ-dependent Inhibition of the AKT Pathway. EMBO Mol Med. 2016 May 2;8 (5) :511-26.