PX-12

PX-12 (IV-2) is an irreversible inhibitor of Thioredoxin-1 (Trx-1) ; inhibits the growth of MCF-7 and HT-29 cells with IC50 values of 1.9 and 2.9 μM, respectively.

Product Specifications

CAS Number

[141400-58-0]

Product Name Alternative

IV-2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PX-12.html

Purity

99.87

Solubility

DMSO : ≥ 44.7 mg/mL|Ethanol : 50 mg/mL (ultrasonic)

Smiles

CC(CC)SSC1=NC=CN1

Molecular Formula

C7H12N2S2

Molecular Weight

188.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Welsh SJ, et al. The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation. Mol Cancer Ther. 2003 Mar;2 (3) :235-43.|[2]Metcalfe C, et al. Thioredoxin Inhibitors Attenuate Platelet Function and Thrombus Formation. PLoS One. 2016 Oct 7;11 (10) :e0163006|[3]Ramanathan RK, et al. A Phase I pharmacokinetic and pharmacodynamic study of PX-12, a novel inhibitor of thioredoxin-1, in patients with advanced solid tumors. Clin Cancer Res. 2007 Apr 1;13 (7) :2109-14.|[4]Wang F, et al. Thioredoxin-1 inhibitor, 1-methylpropyl 2-imidazolyl disulfide, inhibits the growth, migration and invasion of colorectal cancer cell lines. Oncol Rep. 2015 Feb;33 (2) :967-73.|[5]Lou M, et al. Physical interaction between human ribonucleotide reductase large subunit and thioredoxin increases colorectal cancer malignancy. J Biol Chem. 2017 Jun 2;292 (22) :9136-9149.