Piceatannol 3'-O-glucoside

Piceatannol 3'-O-glucoside, an active component of Rhubarb, activates endothelial nitric oxide (NO) synthase through inhibition of arginase activity with IC50s of 11.22 μM and 11.06 μM against arginase I and arginase II, respectively.

Product Specifications

CAS Number

[94356-26-0]

Product Name Alternative

Quzhaqigan

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Arginase; NO Synthase

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Piceatannol_3_acute_-O-glucoside.html

Purity

99.87

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC(/C=C/C3=CC(O)=CC(O)=C3)=CC=C2O

Molecular Formula

C20H22O9

Molecular Weight

406.38

Precautions

H302+H312+H332

References & Citations

[1]Woo A, et al. Piceatannol-3'-O-beta-D-glucopyranoside as an active component of rhubarb activates endothelial nitric oxide synthase through inhibition of arginase activity. Exp Mol Med. 2010 Jul 31;42 (7) :524-32.|[2]Woo A, et al. Arginase inhibition by piceatannol-3'-O-β-D-glucopyranoside improves endothelial dysfunctionvia activation of endothelial nitric oxide synthase in ApoE-null mice fed a high-cholesterol diet. Int J Mol Med. 2013 Apr;31 (4) :803-10.