Avasopasem manganese

Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase mimetic that rapidly and specifically converts O2*- to hydrogen peroxide (H2O2), arresting the initiation of this cascade. Avasopasem manganese can be used for the research of severe oral mucositis (SOM) and cancer[1].

Product Specifications

CAS Number

[435327-40-5]

Product Name Alternative

GC-4419; M-40419

UNSPSC

12352005

Target

Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/avasopasem-manganese.html

Purity

96.07

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

[Cl-][Mn+2]1234([N]5=C6C[NH]1[C@](CCCC7)([H])[C@@]7([H])[NH]2CC[NH]3[C@]8([H])[C@@](CCCC8)([H])[NH]4CC5=CC=C6)[Cl-]

Molecular Formula

C21H35Cl2MnN5

Molecular Weight

483.38

References & Citations

[1]Anderson CM, et al. Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer [published correction appears in J Clin Oncol. 2020 Jan 20;38 (3) :288]. J Clin Oncol. 2019;37 (34) :3256-3265.