KIRA6

KIRA6 is an advanced small-molecule IRE1α RNase kinase inhibitor with an IC50 of 0.6 µM[2]. KIRA6 can trigger an apoptotic response[1].

Product Specifications

CAS Number

[1589527-65-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IRE1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/KIRA6.html

Concentration

10mM

Purity

99.86

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=C3C=CC=CC3=C(C4=C5C(N)=NC=CN5C(C(C)(C)C)=N4)C=C2

Molecular Formula

C28H25F3N6O

Molecular Weight

518.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Mahameed M, et al. The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors. Cell Death Dis. 2019 Apr 1;10 (4) :300.|[2]Ghosh R, et al. Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 2014 Jul 31;158 (3) :534-48.