UNC569
UNC569 is a potent, reversible, ATP-competitive and orally active Mer kinase inhibitor with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC569 also inhibits Axl and Tyro3 with IC50s of 37 nM and 48 nM, respectively. UNC569 can be used for acute lymphoblastic leukemia (ALL) and atypical teratoid/rhabdoid tumors research[1][2]
Product Specifications
CAS Number
1350547-65-7
Product Name Alternative
Tyrphostin NT157
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/unc569.html
Concentration
10mM
Purity
99.92
Solubility
DMSO : 31.25 mg/mL (ultrasonic)
Smiles
FC1=CC=C(C2=NN(C[C@H]3CC[C@H](N)CC3)C4=NC(NCCCC)=NC=C42)C=C1
Molecular Formula
C22H29FN6
Molecular Weight
396.50
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl; Mer; Tyro3
Available Sizes
Frequently Asked Questions
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