ABH (hydrochloride)

ABH (hydrochloride) is an orally active arginase inhibitor (Ki = 8.5 nM) . ABH hydrochloride promotes NO production and reduces the expression of inflammatory response-related molecules (ICAM-1, VCAM-1, MCP-1) . ABH hydrochloride improves erectile function, reduces lung damage, promotes wound healing, reduces arterial blood pressure, and improves vascular fibrosis[1][2][3][4][5][6][7][8][9][10][11].

Product Specifications

CAS Number

[194656-75-2]

UNSPSC

12352211

Hazard Statement

H302, H315, H319

Target

Arginase; Integrin; NO Synthase

Type

Reference compound

Related Pathways

Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/abh-hydrochloride.html

Purity

99.90

Solubility

|H2O : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H](CCCCB(O)O)N)O.[H]Cl

Molecular Formula

C6H15BClNO4

Molecular Weight

211.45

Precautions

H302, H315, H319

References & Citations

[1]Vadon-Legoff S, et al. Improved and high yield synthesis of the potent arginase inhibitor: 2 (S) -amino-6-boronohexanoic acid. Organic process research & development, 2005, 9 (5) : 677-679|[2]Wang L, et al. Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia. Microvasc Res. 2015 Mar;98:1-8.|[3]Tsai P, et al. Effect of the mammalian arginase inhibitor 2 (S) -amino-6-boronohexanoic acid on Bacillus anthracis arginase. Curr Microbiol. 2012 Apr;64 (4) :379-84.|[4]Segal R, et al. Chronic oral administration of the arginase inhibitor 2 (S) -amino-6-boronohexanoic acid (ABH) improves erectile function in aged rats. J Androl. 2012 Nov-Dec;33 (6) :1169-75.|[5]Kavalukas SL, et al. Arginase inhibition promotes wound healing in mice. Surgery. 2012 Feb;151 (2) :287-95.|[6]Cho JS, et al. The effects of arginase inhibitor on lung oxidative stress and inflammation caused by pneumoperitoneum in rats. BMC Anesthesiol. 2015 Sep 28;15:129.|[7]Yao L, et al. Obesity-induced vascular inflammation involves elevated arginase activity. Am J Physiol Regul Integr Comp Physiol. 2017 Nov 1;313 (5) :R560-R571.|[8]Mehl A, et al. Effect of arginase inhibition on pulmonary L-arginine metabolism in murine Pseudomonas pneumonia. PLoS One. 2014 Mar 3;9 (3) :e90232.|[9]Krause BJ, et al. Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by N-Acetylcysteine Supplementation and Arginase Inhibition. Front Physiol. 2018 Jul 24;9:901.|[10]Bhatta A. Involvement of arginase upregulation in diabetes-and angiotensin II-induced vascular dysfunction. 2015.|[11]Toso A, et al. Congenital diaphragmatic hernia: phosphodiesterase-5 and Arginase inhibitors prevent pulmonary vascular hypoplasia in rat lungs. Pediatr Res. 2024 Mar;95 (4) :941-948.