Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

VcMMAE

VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) .

Product Specifications

CAS Number

646502-53-6

Product Name Alternative

MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE; Vedotin

UNSPSC

12352203

Hazard Statement

H300+H330, H340, H360, H370, H372, H412

Target

Drug-Linker Conjugates for ADC; Microtubule/Tubulin

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/VcMMAE.html

Purity

99.98

Solubility

DMSO : ≥ 54 mg/mL|Ethanol : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N2[C@@]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C3=CC=CC=C3)=O)([H])CCC2)=O)C)=O)=O)=O)C=C1)=O)=O)NC(CCCCCN4C(C=CC4=O)=O)=O

Molecular Formula

C68H105N11O15

Molecular Weight

1316.63

Precautions

H300+H330, H340, H360, H370, H372, H412

References & Citations

[1]Okeley, et al. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate. Clinical Cancer Research (2010), 16 (3), 888-897.|[2]Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75 (7) :1376-87.|[3]Jianmin Fang, et al. Anti-her2 antibody and conjugate thereof. US 20160304621 A1.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture and light)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Auristatin

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

MYB30 Antibody
orb792531 2 mg

MYB30 Antibody

Sign In for Pricing
View Details
Temporin SHF
TP2743-01 10 mg

Temporin SHF

Sign In for Pricing
View Details
Temporin SHF
TP2743-02 50 mg

Temporin SHF

Sign In for Pricing
View Details
EC-1456
orb2663334-01 50 mg

EC-1456

Sign In for Pricing
View Details
EC-1456
orb2663334-02 10 mg

EC-1456

Sign In for Pricing
View Details
CD11a (Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide, Integrin alpha-L, ITGAL, Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain, LFA 1 alpha (LFA1A), Ly15, Ly21, Lymphocyte function associated antigen 1, p180) (FITC)
168662-AF-FITC 100 µL

CD11a (Antigen CD11A (p180), lymphocyte function associated antigen 1, alpha polypeptide, Integrin alpha-L, ITGAL, Leukocyte Adhesion Glycoprotein LFA1 Alpha Chain, LFA 1 alpha (LFA1A), Ly15, Ly21, Lymphocyte function associated antigen 1, p180) (FITC)

Sign In for Pricing
View Details