VcMMAE
VcMMAE (mc-vc-PAB-MMAE) is a agent-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) .
Product Specifications
CAS Number
646502-53-6
Product Name Alternative
MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE; Vedotin
UNSPSC
12352203
Hazard Statement
H300+H330, H340, H360, H370, H372, H412
Target
Drug-Linker Conjugates for ADC; Microtubule/Tubulin
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/VcMMAE.html
Purity
99.98
Solubility
DMSO : ≥ 54 mg/mL|Ethanol : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
Molecular Formula
C68H105N11O15
Molecular Weight
1316.63
Precautions
H300+H330, H340, H360, H370, H372, H412
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Auristatin
Available Sizes
Frequently Asked Questions
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