RS 23597-190

RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits Serotonin (HY-B1473A) -induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose[1][2].

Product Specifications

CAS Number

[149719-06-2]

Product Name Alternative

EP-A-501322

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/rs-23597-190.html

Purity

99.06

Solubility

H2O : 5 mg/mL (ultrasonic; warming) |DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(OCCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC.Cl

Molecular Formula

C16H24Cl2N2O3

Molecular Weight

363.28

References & Citations

[1]Eglen RM, et al. RS 23597-190: a potent and selective 5-HT4 receptor antagonist. Br J Pharmacol. 1993 Sep;110 (1) :119-26.|[2]Du Y, et al. Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J. 2015 May;29 (5) :2194-204.