MLS1082
Product Specifications
UNSPSC Description
MLS1082 is a pyrimidone-based D1-like dopamine receptor positive allosteric modulator, with an EC50 of 123 nM for DA-stimulated G protein signaling[1].
Target Antigen
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mls1082.html
Purity
99.55
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=CC=C2)C(C3CCCCC3)=NC(N(C)C4=C5C=CC=C4)=C1C5=O
Molecular Weight
385.46
References & Citations
[1]Kathryn D Luderman, et al. Development of pyrimidone D1 dopamine receptor positive allosteric modulators. Bioorg Med Chem Lett. 2021 Jan 1;31:127696.|[2]Kathryn D Luderman, et al. Identification of Positive Allosteric Modulators of the D 1 Dopamine Receptor That Act at Diverse Binding Sites. Mol Pharmacol. 2018 Oct;94(4):1197-1209.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123837/MLS1082-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123837/MLS1082-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
883958-36-9
Available Sizes
Curated Selection
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