Benzo[a]pyrene

Benzo[a]pyrene shows lung carcinogenicity in animal models, and it is frequently used in chemoprevention studies.

Product Specifications

CAS Number

[50-32-8]

Product Name Alternative

3,4-Benzopyrene

UNSPSC

12352005

Hazard Statement

H316, H317, H340, H350, H360, H400, H410

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Benzo-a-pyrene.html

Purity

99.97

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C12=C(C=C3)C=C(C=CC=C4)C4=C1C=CC5=CC=CC3=C25

Molecular Formula

C20H12

Molecular Weight

252.31

Precautions

H316, H317, H340, H350, H360, H400, H410

References & Citations

[1]Saeko Onami, et al. Dosimetry for lung tumorigenesis induced by urethane, 4- (N-methyl-N-nitrosamino) -1- (3-pyridyl) -1-butanone (NNK), and benzo[a]pyrene (B[a]P) in A/JJmsSlc mice. J Toxicol Pathol. 2017 Jul; 30 (3) : 209–216.|[2]Yeo CD, et al. Roflumilast treatment inhibits lung carcinogenesis in benzo (a) pyrene-induced murine lung cancer model. Eur J Pharmacol. 2017 Oct 5;812:189-|[3]Foth H, et al. Pharmacokinetics of low doses of benzo [a] pyrene in the rat[J]. Food and chemical toxicology, 1988, 26 (1) : 45-51.|[4]Anandakumar P, et al. Capsaicin inhibits benzo (a) pyrene-induced lung carcinogenesis in an in vivo mouse model. Inflamm Res. 2012 Nov;61 (11) :1169-75.|[5]Kasala ER, et al. Benzo (a) pyrene induced lung cancer: Role of dietary phytochemicals in chemoprevention. Pharmacol Rep. 2015 Oct;67 (5) :996-1009.