BVDU 5′-Triphosphate
BVDU 5′-Triphosphate is an antivirus agent with 5′-Triphosphate label, targeting viral DNA polymerase. BVDU 5′-Triphosphate shows excellent selectivity against varicella-zoster virus (VZV) and herpes simplex virus type 1 (HSV-1), due to a specific phosphorylation by the virus-encoded thymidine kinase.
Product Specifications
CAS Number
77222-61-8
Product Name Alternative
(E) -5- (2-Bromovinyl) -dUTP; BVdUTP
UNSPSC
12352005
Target
DNA/RNA Synthesis; HSV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/bvdu-5-triphosphate.html
Solubility
10 mM in DMSO
Smiles
OP(OP(OP(O)(OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C(/C=C/Br)=C2)=O)=O)O1)=O)(O)=O)(O)=O
Molecular Formula
C11H16BrN2O14P3
Molecular Weight
573.08
References & Citations
[1]De Clercq E. Discovery and development of BVDU (brivudin) as a therapeutic for the treatment of herpes zoster. Biochem Pharmacol. 2004 Dec 15;68 (12) :2301-15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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