YCH3124
YCH3124 (compound Z33) is a USP7 inhibitor (IC50=41.9 nM) with antitumor activity. YCH3124 has good in vitro antiproliferative activity against various tumor cells including LNCaP (IC50=3.6 nM) and CHP-212 (IC50=9.9 nM) . In addition, YCH3124 disrupts cell cycle progression by restricting G1 phase and induces apoptosis in CHP-212 cells[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Deubiquitinase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ych3124.html
Smiles
O=C1N(CC2(O)CCN(C(C[C@@H](C)C3=CC=CC=C3)=O)CC2)C=NC4=C1C=CN4C5=CC=C(OC)C(OC)=C5
Molecular Formula
C30H34N4O5
Molecular Weight
530.61
References & Citations
[1]Zhen Zhuang, et al. "Discovery of pyrrolo [2, 3-d] pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy." European Journal of Medicinal Chemistry (2024) : 116752.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
USP7
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