BCI (hydrochloride)
Product Specifications
UNSPSC Description
BCI ((E)-BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research[1][2].
Target Antigen
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/e-z-bci-hydrochloride.html
Purity
99.93
Solubility
DMSO : 15.62 mg/mL (ultrasonic)
Smiles
O=C1/C(C(NC2CCCCC2)C3=C1C=CC=C3)=C/C4=CC=CC=C4.Cl
Molecular Weight
353.89
References & Citations
[1]Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15(10):1436-45.|[2]Zhang F, et al. DUSP6 Inhibitor (E/Z)-BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway. Inflammation. 2019 Apr;42(2):672-681.Cancer Med. 2024 Oct;13(19):e70276.|Cancers (Basel). 2023 Sep 6, 15(18), 4442.|Development. 2023 Feb 13;dev.201090.|Phytother Res. 2023 Mar 3.|bioRxiv. 2024 Feb 5.|Cells. 2022 Feb 19;11(4):732.|Dis Model Mech. 2023 May 1;16(5):dmm049662.|Int Immunopharmacol. 2024 Sep 30;143(Pt 1):113280.|Kaohsiung J Med Sci. 2022 Dec 16.|Neural Regen Res. 2023.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115502A/BCI-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115502A/BCI-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
95130-23-7
Available Sizes
Curated Selection
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