BCI (hydrochloride)

BCI ((E) -BCI) hydrochloride is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI hydrochloride shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI hydrochloride can be used in inflammatory disease research[1][2].

Product Specifications

CAS Number

[95130-23-7]

Product Name Alternative

(E) -BCI (hydrochloride)

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/e-z-bci-hydrochloride.html

Purity

99.93

Solubility

DMSO : 15.62 mg/mL (ultrasonic)

Smiles

O=C1/C(C(NC2CCCCC2)C3=C1C=CC=C3)=C/C4=CC=CC=C4.Cl

Molecular Formula

C22H24ClNO

Molecular Weight

353.89

References & Citations

[1]Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15 (10) :1436-45.|[2]Zhang F, et al. DUSP6 Inhibitor (E/Z) -BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway. Inflammation. 2019 Apr;42 (2) :672-681.