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UNC-2170

UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 µM; Kd=22 µM) . UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB) [1].

Product Specifications

CAS Number

1648707-58-7

Product Name Alternative

PQQ (disodium salt); Methoxatin (disodium salt),PQQ; Methoxatin

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/unc-2170.html

Purity

98.84

Solubility

DMSO : 100 mg/mL (ultrasonic) |Methanol : 125 mg/mL (ultrasonic)

Smiles

O=C(NCCCNC(C)(C)C)C1=CC=CC(Br)=C1

Molecular Formula

C14H21BrN2O

Molecular Weight

313.23

References & Citations

[1]Perfetti MT, et al. Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. ACS Chem Biol. 2015;10 (4) :1072-1081.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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