Cyclin D1 (Phospho Ser90) rabbit pAb

Disease: A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t (11;14) (q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle. Disease: A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM: 254500]. Translocation t (11;14) (q13;q32) with the IgH locus. Disease: A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM: 168461]. Translocation t (11;11) (q13;p15) with the parathyroid hormone (PTH) enhancer. function: Essential for the control of the cell cycle at the G1/S (start) transition. online information: The Singapore human mutation and polymorphism database, PTM: Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest. PTM: Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex. similarity: Belongs to the cyclin family. similarity: Belongs to the cyclin family. Cyclin D subfamily. subunit: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.