N-Myristoyl-Lys-Arg-Thr-Leu-Arg

N-Myristoyl-Lys-Arg-Thr-Leu-Arg is a protein kinase C (PKC) inhibitor with an IC50 value of 75 μM. N-Myristoyl-Lys-Arg-Thr-Leu-Arg inhibits IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat[1].

Product Specifications

CAS Number

[125678-68-4]

UNSPSC

12352209

Target

PKC

Type

Peptides

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/n-myristoyl-lys-arg-thr-leu-arg.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)[C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC(CCCCCCCCCCCCC)=O)=O

Molecular Formula

C42H82N12O8

Molecular Weight

883.18

References & Citations

[1]Ioannides CG, et, al. Inhibition of IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat by a novel peptide inhibitor of protein kinase C. Cell Immunol. 1990 Nov;131 (1) :242-52.