αC-Conotoxin PrXA

αC-Conotoxin PrXA is a paralytic peptide neurotoxin and a competitive nAChR antagonist, with IC50s of 1.8 nM (α1β1εδ, adult) and 3.0 nM (α1β1γδ, fetal), respectively. αC-Conotoxin PrXA competes with α-bungarotoxin at the α/δ and α/γ subunit interfaces of the nAChR, shows high specificity against neuromuscular nAChR[1].

O=C([C@H]1N(CCC1)C([C@H](CCCCN)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@@H](NC([C@H]([C@@H](C)CC)NC(CNC([C@@H](NC([C@@H](N)[C@H](O)C)=O)CC2=CC=C(C=C2)O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O)=O)N4[C@@H](C[C@H](C4)O)C(N[C@H](C(N[C@@H](CO)C(N[C@@H]5C(N[C@@H](C)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(NCC(NCC(N[C@@H](CSSC5)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N6[C@@H](CCC6)C(N7[C@@H](C[C@H](C7)O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N8[C@@H](C[C@H](C8)O)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCCCN)C(N[C@H](C(N)=O)CCC(O)=O)=O)=O)CC9=CC=CC=C9)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC%10=CC=CC=C%10)=O