Amino-Tri- (carboxyethoxymethyl) -methane

Amino-Tri- (carboxyethoxymethyl) -methane is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Amino-Tri- (carboxyethoxymethyl) -methan is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Product Specifications

CAS Number

[174362-95-9]

Product Name Alternative

eFT508,eFT508 (hydrochloride)

UNSPSC

12352203

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amino-tri-carboxyethoxymethyl-methane.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

NC(COCCC(O)=O)(COCCC(O)=O)COCCC(O)=O

Molecular Formula

C13H23NO9

Molecular Weight

337.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Markus Ribbert, et al. Self coupling recombinant antibody fusion proteins. WO2009013359A2.|[2]David Margulies, et al. Fluorescent molecular sensor for targeting changes in protein surfaces, and methods of use thereof. WO2015166491A2.