FLI-06
FLI-06 is an inhibitor of Notch signaling with an EC50 of 2.3 μM.
Product Specifications
CAS Number
[313967-18-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Notch
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/FLI-06.html
Purity
99.88
Solubility
DMSO : ≥ 38 mg/mL
Smiles
O=C(C1=C(C)NC2=C(C(CC(C)(C)C2)=O)C1C3=CC=C([N+]([O-])=O)C=C3)OC4CCCCC4
Molecular Formula
C25H30N2O5
Molecular Weight
438.52
Precautions
H315, H319, H335
References & Citations
[1]Kramer A, et al. Small molecules intercept Notch signaling and the early secretory pathway. Nat Chem Biol. 2013 Nov;9 (11) :731-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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