7,8-Dihydroneopterin

7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase (iNOS) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases[1].

Product Specifications

CAS Number

[1218-98-0]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Endogenous Metabolite; NO Synthase

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/7-8-dihydroneopterin.html

Purity

99.79

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1NC(N)=NC2=C1N=C([C@H](O)[C@H](O)CO)CN2

Molecular Formula

C9H13N5O4

Molecular Weight

255.23

Precautions

H315, H319, H335

References & Citations

[1]C Speth, et al. Inflammation Marker 7,8-dihydroneopterin Induces Apoptosis of Neurons and Glial Cells: A Potential Contribution to Neurodegenerative Processes. Immunobiology. 2000 Nov;202 (5) :460-76.