WDR5-IN-6
WDR5-IN-6 is a WDR5 inhibitor, targeting to WBM site. WDR5-IN-6 inhibits cell proliferation of neuroblastoma cell lines with potent anti-tumor activity. WDR5-IN-6 shows high synergy with OICR-9429 , a WDR5 inhibitor targeting to WIN site. WDR5-IN-6 can be used for reasearch in neuroblastoma[1].
Product Specifications
CAS Number
326901-92-2
UNSPSC
12352005
Target
WDR5
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wdr5-in-6.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(Cl)=CC=C1Cl)(N2C=NC3=C2C=CC=C3)=O
Molecular Formula
C13H8Cl2N2O2S
Molecular Weight
327.19
References & Citations
[1]Han QL, et al. Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma. Acta Pharmacol Sin. 2023 Apr;44 (4) :877-887.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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