Oxiconazole nitrate

Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2) -mediated autophagy arrest[1][2][3].

Product Specifications

CAS Number

[64211-46-7]

Product Name Alternative

Ro 13-8996

UNSPSC

12352005

Hazard Statement

H272, H315, H319

Target

Antibiotic; Cytochrome P450; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Oxiconazole_nitrate.html

Purity

98.0

Solubility

DMSO : ≥ 100 mg/mL

Smiles

[O-][N+](O)=O.ClC1=CC=C(/C(CN2C=CN=C2)=N/OCC3=CC=C(Cl)C=C3Cl)C(Cl)=C1

Molecular Formula

C18H14Cl4N4O4

Molecular Weight

492.14

Precautions

H272, H315, H319

References & Citations

[1]Rossello A, et al. Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole. J Med Chem. 2002 Oct 24;45 (22) :4903-12.|[2]Svecova L, et al. Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. Drug Metab Dispos. 2008 Feb;36 (2) :339-48.|[3]Shi J, et al. Repurposing Oxiconazole against Colorectal Cancer via PRDX2-mediated Autophagy Arrest. Int J Biol Sci. 2022 May 21;18 (9) :3747-3761.