Tioconazole
Tioconazole (UK-20349) is a broad-spectrum antifungal imidazole derivative. Tioconazole inhibits several dermatophytes and yeasts, with MIC50 values of less than 3.12 mg/L and 9 mg/L, respectively. Additionally, Tioconazole exhibits anti-parasitic activity. Tioconazole exerts anticancer activity by inhibiting the PI3K/AKT/mTOR signaling pathway and blocking autophagy. Tioconazole is applicable for research in the fields of anti-infection and anticancer therapy[1][2][3][4][5].
Product Specifications
CAS Number
[65899-73-2]
Product Name Alternative
UK-20349
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt; Antibiotic; Autophagy; Fungal; mTOR; Parasite; PI3K
Type
Reference compound
Related Pathways
Anti-infection; Autophagy; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Tioconazole.html
Purity
99.90
Solubility
DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL
Smiles
ClC1=CC=C(C(OCC2=C(Cl)SC=C2)CN3C=CN=C3)C(Cl)=C1
Molecular Formula
C16H13Cl3N2OS
Molecular Weight
387.71
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0319/Tioconazole-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0319/Tioconazole-SDS-MedChemExpress.pdf
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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