5-Hydroxylansoprazole

5-Hydroxylansoprazole (AG1908) is an active metabolite of Lansoprazole in plasma. Lansoprazole is metabolized by CYP2C19 forming 5-Hydroxylansoprazole. Lansoprazole is a gastric proton-pump inhibitor and is effective in the treatment of various peptic diseases[1][2].

Product Specifications

CAS Number

[131926-98-2]

Product Name Alternative

AG1908

UNSPSC

12352005

Target

Proton Pump

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/5-hydroxylansoprazole.html

Purity

99.0

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=CC=C2N=C(NC2=C1)S(CC3=NC=CC(OCC(F)(F)F)=C3C)=O

Molecular Formula

C16H14F3N3O3S

Molecular Weight

385.36

References & Citations

[1]Xu HR, et al. The effect of CYP2C19 activity on pharmacokinetics of lansoprazole and its active metabolites in healthy subjects. Pharm Biol. 2010 Aug;48 (8) :947-52. doi: 10.3109/13880200903300220.|[2]Katarína Kostolanská, et al. Determination of lansoprazole, 5-hydroxylansoprazole, and lansoprazole sulfone in human plasma for CYP2C19 and CYP3A4 phenotyping. Chemical Papers. volume 73, pages2955–2963 (2019) .