Naloxone benzoylhydrazone

Naloxone benzoylhydrazone (NalBzoH) is a mixed agonist/antagonist. Naloxone benzoylhydrazone is a prototypic κ3-opioid receptor agonist, and a partial agonist at the cloned μ and δ opioid receptors, and an antagonist at opioid-like NOP receptors. Naloxone benzoylhydrazone has potently analgesia effect[1][2][3].

Product Specifications

CAS Number

[119630-94-3]

Product Name Alternative

NalBzoH

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/naloxone-benzoylhydrazone.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O[C@]12[C@@]34C5=C(C(O)=CC=C5C[C@@]2([H])N(CC=C)CC4)O[C@@]3([H])/C(CC1)=N/NC(C6=CC=CC=C6)=O

Molecular Formula

C26H27N3O4

Molecular Weight

445.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Olianas MC, et al. Agonist activity of naloxone benzoylhydrazone at recombinant and native opioid receptors. Br J Pharmacol. 2006 Feb;147 (4) :360-70.|[2]Connor M, et al. Has the sun set on kappa3-opioid receptors? Br J Pharmacol. 2006 Feb;147 (4) :349-50.|[3]Paul D, et al. Naloxone benzoylhydrazone (NalBzoH) analgesia. J Pharmacol Exp Ther. 1990 Nov;255 (2) :769-74.|[4]Gistrak MA, et al. Pharmacological actions of a novel mixed opiate agonist/antagonist: naloxone benzoylhydrazone. J Pharmacol Exp Ther. 1989 Nov;251 (2) :469-76.