Cetraxate (hydrochloride)

Cetraxate hydrochloride (DV-1006), an orally active anti-ulcer agent with mucosal protective effects, can be used for gastric ulcers research[1]. Cetraxate hydrochloride is a potent acrosomal proteinase acrosin inhibitor with a Ki and an IC50 of 0.94 μM and 3.3 μM, respectively[2].

Product Specifications

CAS Number

[27724-96-5]

Product Name Alternative

DV-1006

UNSPSC

12352005

Target

Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cetraxate-hydrochloride.html

Purity

99.37

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

OC(CCC(C=C1)=CC=C1OC([C@H]2CC[C@@H](CC2)CN)=O)=O.Cl

Molecular Formula

C17H24ClNO4

Molecular Weight

341.83

References & Citations

[1]Fumihiko Katagiri, et al. Cetraxate raises levels of calcitonin gene-related peptide and substance P in human plasma. J Pharm Pharmacol. 2004 Apr;56 (4) :557-61.|[2]H Sumi, et al. Inhibitors of the acrosomal proteinase acrosin: human urinary trypsin inhibitor (UTI) and 4- (2-carboxyethyl) phenyl trans 4-aminomethylcyclohexanecarboxylate hydrochloride (DV-1006) . Experientia. 1980 Sep 15;36 (9) :1103-4.