Entecavir
Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.
Product Specifications
CAS Number
142217-69-4
Product Name Alternative
BMS200475; SQ34676
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H332, H335
Target
HBV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Entecavir.html
Purity
99.98
Solubility
DMSO : ≥ 44 mg/mL
Smiles
NC(N1)=NC(C2=C1N([C@@H](C[C@H](O)[C@H]3CO)C3=C)C=N2)=O
Molecular Formula
C12H15N5O3
Molecular Weight
277.28
Precautions
H302, H315, H319, H332, H335
References & Citations
[1]Innaimo SF, et al. Identification of?BMS-200475?as a potent and selective inhibitor of hepatitis B virus. Antimicrob Agents Chemother. 1997 Jul;41 (7) :1444-9.|[2]Rivkin A, et al. A review of entecavir in the treatment of chronic hepatitis B infection. Curr Med Res Opin.?2005 Nov;21 (11) :1845-57.|[3]Genovesi EV, et al. Efficacy of the carbocyclic 2'-deoxyguanosine nucleoside?BMS-200475?in the woodchuck model of hepatitis B virus infection. Antimicrob Agents Chemother.?1998 Dec;42 (12) :3209-18.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched
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