Entecavir

Entecavir (SQ 34676; BMS 200475) is a potent and selective inhibitor of HBV, with an EC50 of 3.75 nM in HepG2 cell.

Product Specifications

CAS Number

[142217-69-4]

Product Name Alternative

BMS200475; SQ34676

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H332, H335

Target

HBV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/Entecavir.html

Purity

99.98

Solubility

DMSO : ≥ 44 mg/mL

Smiles

NC(N1)=NC(C2=C1N([C@@H](C[C@H](O)[C@H]3CO)C3=C)C=N2)=O

Molecular Formula

C12H15N5O3

Molecular Weight

277.28

Precautions

H302, H315, H319, H332, H335

References & Citations

[1]Innaimo SF, et al. Identification of?BMS-200475?as a potent and selective inhibitor of hepatitis B virus. Antimicrob Agents Chemother. 1997 Jul;41 (7) :1444-9.|[2]Rivkin A, et al. A review of entecavir in the treatment of chronic hepatitis B infection. Curr Med Res Opin.?2005 Nov;21 (11) :1845-57.|[3]Genovesi EV, et al. Efficacy of the carbocyclic 2'-deoxyguanosine nucleoside?BMS-200475?in the woodchuck model of hepatitis B virus infection. Antimicrob Agents Chemother.?1998 Dec;42 (12) :3209-18.