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Alniditan (dihydrochloride)

Alniditan (Alnitidan) dihydrochloride is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects[1][2].

Product Specifications

CAS Number

155428-00-5

Product Name Alternative

Alnitidan (dihydrochloride)

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/alniditan-dihydrochloride.html

Purity

99.70

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

[H]Cl.[H]Cl.C1(NCCCNC[C@H]2CCC3=CC=CC=C3O2)=NCCCN1

Molecular Formula

C17H28Cl2N4O

Molecular Weight

375.34

References & Citations

[1]Limmroth V, et al. Effects of alniditan on neurogenic oedema in the rat dura mater and on contraction of rat basilar artery. Eur J Pharmacol. 1999 Oct 8;382 (2) :103-9.|[2]Lesage AS, et al. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. Br J Pharmacol. 1998 Apr;123 (8) :1655-65.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT1 Receptor; mLAG-3

Available Sizes

Frequently Asked Questions

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