NH-3

NH-3 is an orally active, reversible thyroid hormone receptor (THR) antagonist with an IC50 of 55 nM. NH-3, a derivative of the selective thyromi-metic GC-1, inhibits binding of thyroid hormones to their receptor and that inhibits cofactor recruitment[1][2][3]. NH-3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[447415-26-1]

UNSPSC

12352005

Target

Thyroid Hormone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nh-3.html

Purity

99.41

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)COC1=CC(C)=C(CC2=CC(C#CC3=CC=C([N+]([O-])=O)C=C3)=C(O)C(C(C)C)=C2)C(C)=C1

Molecular Formula

C28H27NO6

Molecular Weight

473.52

References & Citations

[1]Latika Singh, et al. Chasing the Elusive Benzofuran Impurity of the THR Antagonist NH-3: Synthesis, Isotope Labeling, and Biological Activity. J Org Chem. 2016 Mar 4;81 (5) :1870-6.|[2]Gary J Grover, et al. Pharmacological profile of the thyroid hormone receptor antagonist NH3 in rats. J Pharmacol Exp Ther. 2007 Jul;322 (1) :385-90.|[3]Wayland Lim, et al. A thyroid hormone antagonist that inhibits thyroid hormone action in vivo. J Biol Chem. 2002 Sep 20;277 (38) :35664-70.