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EST64454 (hydrochloride)

Product Specifications

UNSPSC Description

EST64454 hydrochloride is a selective and orally active sigma-1 receptor antagonist with a Ki of 22 nM. EST64454 hydrochloride has the potential for the research of the pain[1].

Target Antigen

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/est64454-hydrochloride.html

Purity

98.36

Solubility

DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 100 mg/mL

Smiles

CC(N1CCN(CCOCC2=NN(C3=CC=C(F)C(F)=C3)C=C2)CC1)=O.[H]Cl

Molecular Weight

400.85

References & Citations

[1]Díaz JL, et al. EST64454: a Highly Soluble σ1 Receptor Antagonist Clinical Candidate for Pain Management. J Med Chem. 2020;63(23):14979-14988.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-131914A/EST64454-hydrochloride-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-131914A/EST64454-hydrochloride-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1950569-11-5

Available Sizes

Curated Selection

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