CPT-157633

CPT-157633, a difluoro-phosphonomethyl phenylalanine derivative, and is a PTP1B inhibitor. CPT-157633 prevents binge drinking-induced glucose intolerance[1].

Product Specifications

CAS Number

[888213-72-7]

UNSPSC

12352005

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cpt-157633.html

Concentration

10mM

Purity

99.14

Solubility

DMSO : 200 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

FC(C1=CC=C(C[C@H](NS(=O)(C)=O)C(NC)=O)C=C1Br)(P(O)(O)=O)F

Molecular Formula

C12H16BrF2N2O6PS

Molecular Weight

465.20

References & Citations

[1]Lindtner C, et, al. Binge drinking induces whole-body insulin resistance by impairing hypothalamic insulin action. Sci Transl Med. 2013 Jan 30;5 (170) :170ra14.