Nω-Propyl-L-arginine

Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS) [1][2].

Product Specifications

CAS Number

[137361-05-8]

Product Name Alternative

N-omega-Propyl-L-arginine

UNSPSC

12352211

Hazard Statement

H319

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nω-propyl-l-arginine.html

Purity

98.62

Solubility

H2O : ≥ 100 mg/mL

Smiles

N=C(NCCC)NCCC[C@H](N)C(O)=O

Molecular Formula

C9H20N4O2

Molecular Weight

216.28

Precautions

H319

References & Citations

[1]Zhang HQ, et al. Potent and selective inhibition of neuronal nitric oxide synthase by N omega-propyl-L-arginine. J Med Chem. 1997 Nov 21;40 (24) :3869-70.|[2]Klamer D, et al. The neuronal selective nitric oxide synthase inhibitor, Nomega-propyl-L-arginine, blocks the effects of phencyclidine on prepulse inhibition and locomotor activity in mice. Eur J Pharmacol. 2004 Oct 25;503 (1-3) :103-7.