PARP1-IN-33
PARP1-IN-33 (Example 6) is a PARP1 inhibitor (IC50: 0.41 nM) . PARP1-IN-33 has retinal cytoprotective effect, with an EC50 of 0.02 nM (inhibition on MTS activity of H2O2 induced human retinal pigment epithelial cell) [1].
Product Specifications
CAS Number
2640677-68-3
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/parp1-in-33.html
Purity
99.87
Solubility
DMSO : 5.83 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(N2CCN(CCCC3=CC4=C(C(N3)=O)C(F)=CC=C4)CC2)C=C1.Cl
Molecular Formula
C23H24ClFN4O
Molecular Weight
426.91
References & Citations
[1]김은희, et al. Isoquinolinone derivative, preparation method therefor, and pharmaceutical composition, comprising same as active ingredient, for prevention or treatment of poly (adp-ribose) polymerase-1 (parp-1) -associated disease, WO2021086077, WPO, 2021-05-06.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1
Available Sizes
Frequently Asked Questions
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