PARP1-IN-33

PARP1-IN-33 (Example 6) is a PARP1 inhibitor (IC50: 0.41 nM) . PARP1-IN-33 has retinal cytoprotective effect, with an EC50 of 0.02 nM (inhibition on MTS activity of H2O2 induced human retinal pigment epithelial cell) [1].

Product Specifications

CAS Number

[2640677-68-3]

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/parp1-in-33.html

Purity

99.87

Solubility

DMSO : 5.83 mg/mL (ultrasonic)

Smiles

N#CC1=CC=C(N2CCN(CCCC3=CC4=C(C(N3)=O)C(F)=CC=C4)CC2)C=C1.Cl

Molecular Formula

C23H24ClFN4O

Molecular Weight

426.91

References & Citations

[1]김은희, et al. Isoquinolinone derivative, preparation method therefor, and pharmaceutical composition, comprising same as active ingredient, for prevention or treatment of poly (adp-ribose) polymerase-1 (parp-1) -associated disease, WO2021086077, WPO, 2021-05-06.