JNJ-10229570

JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.

Product Specifications

CAS Number

[524923-88-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Melanocortin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/JNJ-10229570.html

Purity

98.0

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

COC1=C(C=CC=C1)C(N(C2=C(C=CC=C2)OC)S/3)=NC3=N\C4=CC=CC=C4

Molecular Formula

C22H19N3O2S

Molecular Weight

389.47

Precautions

H302, H315, H319, H335

References & Citations

[1]Eisinger M, et al. A melanocortin receptor 1 and 5 antagonist inhibits sebaceous gland differentiation and the production of sebum-specific lipids. J Dermatol Sci. 2011 Jul;63 (1) :23-32.