10-Deacetylbaccatin III

10-Deacetylbaccatin-III is an intermediate in the preparation process of paclitaxel. 10-Deacetylbaccatin III can be isolated from the dried needles and small branches of the European yew tree (Taxus baccata) . 10-Deacetylbaccatin III exhibits antileishmanial activity[1][2][3][4][5][6].

Product Specifications

CAS Number

[32981-86-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H335, H340, H350, H373

Target

Biochemical Assay Reagents; Drug Intermediate; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Others

Applications

Cancer-programmed cell death

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/10-Deacetylbaccatin-III.html

Purity

99.80

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1=C([C@@H](O)C([C@@]2(C)[C@@]3([H])[C@@](CO4)(OC(C)=O)[C@@]4([H])C[C@@H]2O)=O)C(C)(C)[C@@]([C@H]3OC(C5=CC=CC=C5)=O)(O)C[C@@H]1O

Molecular Formula

C29H36O10

Molecular Weight

544.59

Precautions

H315, H319, H335, H340, H350, H373

References & Citations

[1]Li S, Zhang P, Zhang M, Fu C, Yu L. Functional analysis of a WRKY transcription factor involved in transcriptional activation of the DBAT gene in Taxus chinensis. Plant Biol (Stuttg) . 2013 Jan;15 (1) :19-26.|[2]Naill MC, Kolewe ME, Roberts SC. Paclitaxel uptake and transport in Taxus cell suspension cultures. Biochem Eng J. 2012 Apr 15;63:50-56.|[3]Qayum M, Nisar M, Shah MR, et al. Analgesic and antiinflammatory activities of taxoids from Taxus wallichiana Zucc. Phytother Res. 2012 Apr;26 (4) :552-6.|[4]Kevin Walker and Rodney Croteau. Taxol biosynthesis: Molecular cloning of a benzoyl- CoA:taxane 2α-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli. PNAS, 2000 , 97 (25) : 13591-13596.|[5]Georgopoulou K, et al. In Vitro Activity of 10-Deacetylbaccatin III against Leishmania donovani Promastigotes and Intracellular Amastigotes. Planta Med, 2007, 73 (11) :1081-1088. |[6]Patel R N et al. Enzymatic acetylation of 10-deacetylbaccatin III to baccatin III by C-10 deacetylase from Nocardioides luteus SC 13913. Enzyme and Microbial Technology, 2000, 27 (5) :371-375.