Vormatrigine
Product Specifications
UNSPSC Description
Vormatrigine is an orally active sodium channel inhibitor with anti-epileptic activity. Vormatrigine has a specific inhibitory effect on overactive NaV channels in vitro and has a good inhibitory effect in the maximal electroconvulsive seizure (MES) model. Vormatrigine can be used to study human focal and generalized epilepsy[1][2].
Target Antigen
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vormatrigine.html
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
FC1=C(OCC(F)(F)F)N=CC(C2=CN3C(C(F)(OCC)F)=NN=C3C=C2)=C1
Molecular Weight
406.28
References & Citations
[1]Praxis Precision Medicines, Inc. Preparation of pyridin-3-yl substituted triazolopyrazines, triazolopyridazines, and triazolopyridines as ion channel modulators. World Intellectual Property Organization, WO2019232209 A1 2019-12-05|[2]Praxis Presentation of Epilepsy Program Advances Set for 2024 American Epilepsy Society Annual Meeting
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159819/Vormatrigine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159819/Vormatrigine-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2392951-18-5
Available Sizes
Curated Selection
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