Vormatrigine

Vormatrigine is an orally active sodium channel inhibitor with anti-epileptic activity. Vormatrigine has a specific inhibitory effect on overactive NaV channels in vitro and has a good inhibitory effect in the maximal electroconvulsive seizure (MES) model. Vormatrigine can be used to study human focal and generalized epilepsy[1][2].

Product Specifications

CAS Number

[2392951-18-5]

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/vormatrigine.html

Concentration

10mM

Purity

99.73

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

FC1=C(OCC(F)(F)F)N=CC(C2=CN3C(C(F)(OCC)F)=NN=C3C=C2)=C1

Molecular Formula

C16H12F6N4O2

Molecular Weight

406.28

References & Citations

[1]Praxis Precision Medicines, Inc. Preparation of pyridin-3-yl substituted triazolopyrazines, triazolopyridazines, and triazolopyridines as ion channel modulators. World Intellectual Property Organization, WO2019232209 A1 2019-12-05|[2]Praxis Presentation of Epilepsy Program Advances Set for 2024 American Epilepsy Society Annual Meeting