SARS-CoV S RBD (Biotinylated, sf9, His)

The SARS-CoV Spike glycoprotein (S) has three subunits S1, S2' and S2 through alternative splicing. S protein orchestrates viral entry by attaching the virion to the cell membrane through interactions with human ACE2 and CLEC4M/DC-SIGNR receptors. S protein also impairs target cell killing, cytokine production and down-regulates host tetherin (BST2), countering the antiviral activity of host. SARS-CoV S Protein RBD (Biotinylated, sf9, His) is the recombinant Virus-derived SARS-CoV S protein RBD, expressed by Sf9 insect cells , with C-His labeled tag.

Product Specifications

Product Name Alternative

SARS-CoV S Protein RBD (Biotinylated, sf9, His), Virus, Sf9 insect cells

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/sars-cov-s-protein-rbd-biotinylated-sf9-his.html

Molecular Formula

/ (Gene_ID) AAX16192 (R306-F527) (Accession)

Molecular Weight

Approximately 35.1 kDa, based on SDS-PAGE under reducing conditions.

References & Citations

[1]Onnis A, et al. SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly. J Exp Med. 2023 Feb 6;220 (2) :e20220906.|[2]Hu B, et al. Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA.1 and BA.2. Emerg Microbes Infect. 2022 Dec;11 (1) :2275-2287.