5-Methyl-7-methoxyisoflavone

5-Methyl-7-methoxyisoflavone is an orally active anti-oxidant with remyelinating activity. 5-Methyl-7-methoxyisoflavone inhibits the enzyme aromatase, interfering with the normal metabolic pathways of testosterone. 5-Methyl-7-methoxyisoflavone is a non-steroidal anabolic isoflavone, used as a anabolic agent. 5-Methyl-7-methoxyisoflavone shows better potency increasing muscle mass and endurance than Ipriflavone (HY-N0094) . 5-Methyl-7-methoxyisoflavone can be used for fat loss besides the maintenance of low cholesterol level and strengthen bones. 5-Methyl-7-methoxyisoflavone is the inhibitor for NF-κB[1][2][3][4].

Product Specifications

CAS Number

[82517-12-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cytochrome P450; NF-κB

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/5-methyl-7-methoxyisoflavone.html

Purity

99.13

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C(C2=CC=CC=C2)=COC3=CC(OC)=CC(C)=C13

Molecular Formula

C17H14O3

Molecular Weight

266.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Ningbo Gong, et al. Concomitant polymorphs of methoxyflavone (5-methyl-7-methoxyflavone) . RSC Adv., 2016, 6, 38709-38715.|[2]Agresti C, et al. Oxidative status in multiple sclerosis and off-targets of antioxidants: the case of edaravone[J]. Current Medicinal Chemistry, 2020, 27 (13) : 2095-2105.|[3]Iannone M, et al. An investigation on the metabolic pathways of synthetic isoflavones by gas chromatography coupled to high accuracy mass spectrometry. Rapid Commun Mass Spectrom. 2019 Oct 15;33 (19) :1485-1493. |[4]Lecompte Y, et al. UPLC-ESI-Q-TOF-MS (E) identification of urinary metabolites of the emerging sport nutrition supplement methoxyisoflavone in human subjects. J Pharm Biomed Anal. 2014 Aug 5;96:127-34. |[5]Lee S, et al., Isoflavone derivatives inhibit NF-κB-dependent transcriptional activity. Bioorg Med Chem Lett. 2010 Nov 1;20 (21) :6277-81.|[6]Hyun J, et al., Isoflavones inhibit the clonogenicity of human colon cancer cells. Bioorg Med Chem Lett. 2012 Apr 15;22 (8) :2664-9.