EZ-482
EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas[1].
Product Specifications
CAS Number
[1016456-76-0]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apolipoprotein
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ez-482.html
Concentration
10mM
Purity
98.01
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC(S(=O)(NC2=CC=CC(Cl)=C2)=O)=CC=C1O)CC3=NN(C)C(C4=C3C=CC=C4)=O
Molecular Formula
C23H19ClN4O5S
Molecular Weight
498.94
Precautions
H315, H319, H335
References & Citations
[1]Tridib Mondal, et al. ApoE: In Vitro Studies of a Small Molecule Effector. Biochemistry. 2016 May 10;55 (18) :2613-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ApoE
Available Sizes
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