BVT 2733

BVT 2733 is a potent, selective, and orally active non-steroidal 11β-hydroxydehydrogenase 1 (11β-HSD1) inhibitor. BVT 2733 is potently against the mouse enzyme (IC50=96 nM) over the human enzyme (IC50=3341 nM) . BVT 2733 has the potential for the study of arthritis and obesity related disease[1].

Product Specifications

CAS Number

[376640-41-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

11β-HSD

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/BVT-2733.html

Purity

99.24

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

ClC1=C(C)C(S(NC2=NC(CC(N3CCN(C)CC3)=O)=CS2)(=O)=O)=CC=C1

Molecular Formula

C17H21ClN4O3S2

Molecular Weight

428.96

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhang L, et al. 11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis. Int Immunopharmacol. 2013 Nov;17 (3) :489-94.|[2]Wang L, et al. BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice. PLoS One. 2012;7 (7) :e40056.|[3]11β-hydroxydehydrogenase 1 (11β-HSD1) Inhibitor in Development