Orobol

Orobol is one of the major soy isoflavones and has various pharmacological activities, including anti-skin-aging and anti-obesity effects. Orobol inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM) . Orobol also inhibits PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ) [1][2].

Product Specifications

CAS Number

[480-23-9]

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Casein Kinase; PI3K; VEGFR

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/orobol.html

Purity

99.74

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C2=C(O)C=C(O)C=C2OC=C1C3=CC(O)=C(O)C=C3

Molecular Formula

C15H10O6

Molecular Weight

286.24

Precautions

H302, H312, H332

References & Citations

[1]Kim MH, et al. Lipid Nanoparticles for Enhancing the Physicochemical Stability and Topical Skin Delivery of Orobol. Pharmaceutics. 2020;12 (9) :845. Published 2020 Sep 3.