AM103 (free acid)
AM103 (free acid) is a selective FLAP inhibitor that can block the first step of the LT pathway, which is 5-LO activation. AM103 (free acid) can inhibit the production of LTB4 and cysteinyl leukotrienes (CysLT) . AM103 (free acid) has anti-inflammatory activity in a mouse model of chronic lung inflammation and can extend the survival time of mice injected with platelet-activating factor. AM103 (free acid) can be used for research on respiratory diseases such as asthma[1].
Product Specifications
CAS Number
936349-47-2
UNSPSC
12352005
Target
FLAP
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/am103-free-acid.html
Smiles
O=C(C(C)(CC1=C(C2=C(N1CC3=CC=C(C4=CC=C(OC)N=C4)C=C3)C=CC(OCC5=NC=CC=C5)=C2)SC(C)(C)C)C)O
Molecular Formula
C36H39N3O4S
Molecular Weight
609.78
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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