4-Br-Bnlm
4-Br-Bnlm is a selective inhibitor of glucose-regulated protein 94 (Grp94) with an EC50 value of 0.96 µM. 4-Br-Bnlm reduces the levels of mutant myocilin proteins as well as wild-type myocilin misfold in cells. 4-Br-Bnlm promotes the clearance of toxic formsof myocilin and reduces myocilin toxicity[1][2].
Product Specifications
CAS Number
1654775-71-9
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/4-br-bnlm.html
Concentration
10mM
Purity
99.46
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C(OC)C1=C(O)C=C(O)C(Cl)=C1CCC2=NC=CN2CC3=CC=C(Br)C=C3
Molecular Formula
C20H18BrClN2O4
Molecular Weight
465.72
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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