Neorauflavane
Neorauflavane is a potent tyrosinase inhibitor derived from Campylotropis hirtella, with an IC50 value of 30 nM for tyrosinase monophenolase activity and an IC50 value of 500 nM for diphenolase activity. Neorauflavane can effectively reduce the melanin content of B16 melanoma cells[1].
Product Specifications
CAS Number
[53734-74-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Tyrosinase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/neorauflavane.html
Purity
96.0
Solubility
10 mM in DMSO
Smiles
COC1=C2C(OC[C@@H](C3=C(C=C(O)C=C3)O)C2)=CC4=C1C=CC(C)(C)O4
Molecular Formula
C21H22O5
Molecular Weight
354.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Xuefei Tan, et al. Highly potent tyrosinase inhibitor, neorauflavane from Campylotropis hirtella and inhibitory mechanism with molecular docking. Bioorg Med Chem. 2016 Jan 15;24 (2) :153-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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