Imidaprilat-d3
Imidaprilat-d3 (6366A-d3) is deuterium labeled Imidaprilate. Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease[1].
Product Specifications
CAS Number
1356019-69-6
Product Name Alternative
6366A-d3
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE) ; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Smiles
C[C@H](N[C@@H](CCC1=CC=CC=C1)C(O)=O)C(N2[C@H](CN(C2=O)C([2H])([2H])[2H])C(O)=O)=O
Molecular Formula
C18H20D3N3O6
Molecular Weight
380.41
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kubo M, et al. Pharmacological studies on (4S) -1-methyl-3-[ (2S) -2-[N- ((1S) -1-ethoxycarbonyl-3-phenylpropyl) amino] propionyl]-2-oxo-imidazolidine-4-carboxylic acid hydrochloride (TA-6366), a new ACE inhibitor: I. ACE inhibitory and anti-hypertensive activities. Jpn J Pharmacol. 1990 Jun;53 (2) :201-10.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Available Sizes
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